4.7 Article

Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells

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CANCER LETTERS
卷 261, 期 2, 页码 193-204

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ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.11.012

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L1-CAM; anti-L1 antibody chCE7; Genistein; SKOV3ip cells

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Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells ill vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells. A combination of mAb chCE7 and Genistein strongly reduced the sensitivity of p44/42 (Erk1,2) kinase, Src kinase and Akt kinase to extracellular stimulation with serum, Epidermal Growth Factor and Hepatocyte Growth Factor. The observed synergy of antibodies directed against L1 with Genistein could lead to a new therapeutic option for ovarian cancer. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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