期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 32, 期 4, 页码 158-164出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2007.02.003
关键词
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Multi-component, macromolecular complexes perform essential cellular functions that require spatial or temporal coordination of activities. Complexes also facilitate coregulation of protein amounts and cellular localization of individual components. We propose a novel function of multi-component complexes as depots for regulatory proteins that, upon release, acquire new auxiliary functions. We further propose that component release is inducible and context-dependent. We describe two cases in which multi-component assemblies-the ribosome and tRNA multi-synthetase complex - function as depots. Both complexes have crucial roles in supporting protein synthesis but they also release regulatory proteins for inflammation-responsive, transcript-specific translational control. Recent evidence indicates that other macromolecular assemblies might be sources for proteins with auxiliary functions, and the depot mechanism might be widespread in nature.
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