期刊
CURRENT OPINION IN MICROBIOLOGY
卷 10, 期 2, 页码 164-168出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2007.03.008
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- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067955] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM067955, R01 GM67955] Funding Source: Medline
Appreciation for the prevalence and diversity of noncoding, small RNAs (sRNAs) has grown enormously in the past decade. A major role for sRNAs in all organisms is to regulate gene expression, often at the level of mRNA translation or stability. However, a few sRNAs have been shown to function by regulating transcription. The bacterial 6S RNA was the first sRNA shown to inhibit transcription by binding directly to the housekeeping holoenzyme form of RNA polymerase (i.e. sigma(70)-RNA polymerase in E. coli). It resides within the active site of RNA polymerase, blocks access to promoter DNA and, surprisingly, is used as a template for RNA synthesis. 6S RNA regulation of transcription leads to altered cell survival, perhaps by redirecting resource utilization under nutrient-limiting conditions.
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