期刊
CANCER LETTERS
卷 272, 期 2, 页码 260-267出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.06.015
关键词
Clear cell RCC; Papillary RCC; Copy number alterations; Pathological features; Transforming growth factor; Beta-induced gene
类别
资金
- Gerber Foundation
- Hauenstein Foundation
- Van Andel Foundation
- Amway Japan Limited
- Singapore Cancer Society
We report and characterize the copy number alterations (CNAs) in 35 clear cell and 12 papillary renal cell carcinomas (RCC) using Affymetrix 100K SNP arrays. Novel gain and loss regions are identified in both subtypes. In addition, statistically significant CNA are detected and associated with the pathological features: VHL mutation status, tumor grades, and sarcomatoid component in clear cell RCC and in types 1 and 2 of papillary RCC. Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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