期刊
CANCER LETTERS
卷 267, 期 1, 页码 106-115出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.03.010
关键词
hepatoma; apoptosis; anoikis; synoikis-like; ANGPTL4
类别
Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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