期刊
CANCER LETTERS
卷 263, 期 2, 页码 212-222出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.01.006
关键词
HBV; aflatoxin; oxidative stress; hepatocellular carcinoma
类别
资金
- NIEHS NIH HHS [R01 ES005116-15, ES05116, ES09089, P30 ES009089-09, R01 ES005116, P30 ES009089] Funding Source: Medline
Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p < 0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p = 0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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