期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 18, 期 3, 页码 184-195出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2006.12.006
关键词
non-alcoholic steatohepatitis; industrial toxins; non-alcoholic fatty liver disease
资金
- NIAAA NIH HHS [R01AA014371, R21 AA015611, R01AA15970, K01 AA015344-01A1, R01AA010496, R37AA010762] Funding Source: Medline
- NIDDK NIH HHS [R01DK071765] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK071765] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R37AA010762, R01AA010496, R01AA014371, R21AA015611, R01AA015970, K01AA015344] Funding Source: NIH RePORTER
More than 20% of Americans have nonalcoholic fatty liver disease (NAFLD), and this is, by far, the leading cause of abnormal liver enzymes in the United States. Nonalcoholic steatohepatitis (NASH), a more serious form of NAFLD, can proceed to cirrhosis and even hepatocellular carcinoma. These liver diseases represent the hepatic component of the metabolic syndrome, and this spectrum of liver disease represents a major health problem both in the United States and worldwide. Hepatic steatosis is closely linked to nutrition, including obesity, possibly high-fructose corn syrup consumption and consumption of certain types of fats. There are a variety of second insults or hits that appear to transform simple steatosis into NASH, with some of these second hits including certain proinflammatory cytokines, oxidative stress and possibly industrial toxins. In certain underdeveloped countries, it appears likely that industrial toxins play a role in NASH, and there is increasing interest in the potential interaction of industrial toxins and nutrients. Moreover, optimal therapy for NAFLD appears to include lifestyle modification with exercise, diet and weight loss. Certain nutrients may also be of benefit. Important areas for future research are the effect(s) of nutritional supplements on NAFLD/NASH and the effects of industrial toxins. Published by Elsevier Inc.
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