期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 32, 期 3, 页码 118-128出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2007.01.004
关键词
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资金
- Medical Research Council [G0401570] Funding Source: Medline
- MRC [G0401570] Funding Source: UKRI
The APOBEC family of cytidine deaminases inhibit the mobility of diverse retroviruses, retrotransposons and other viruses. Initial reports proposed that these effects were due to the DNA editing capabilities of these enzymes; however, many recent studies have provided evidence suggesting that APOBEC proteins can inhibit these elements by several mechanisms, including editing-dependent and editing-independent processes. Investigating these modes of action and the potential contribution that each one makes to the antiviral activities of various APOBEC proteins is vital if we are to understand how APOBEC proteins protect host genomes from invading nucleic acids.
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