期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 23, 期 2, 页码 256-263出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2006.09.002
关键词
polycyclic aromatic hydrocarbons; phototoxicity; ultraviolet; DNA damage; photomutagenicity; photocarcinogenicity
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in the environment as pollutants in air, water and soil, and some are carcinogenic, being associated with various types of cancer. A majority of the research concerning the biological effects of PAHs has focused on the metabolic activation and DNA adducts leading to mutation and transformation. Although the role of the PAHs as photo sensitizers has received much less attention, investigators have shown that PAHs excited by sunlight induced significant cytotoxicity and several kinds of DNA damage. Some PAHs were recently proved to be photommagenic. In this review, we discuss the influence of PAHs in combination with sunlight focusing on the phototoxicity and cellular DNA damage produced. (c) 2006 Elsevier B.V. All rights reserved.
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