期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 28, 期 3, 页码 142-148出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2007.01.005
关键词
-
The nuclear transcription factor NF-kappa B has a crucial role in the pathogenesis of several human disorders, particularly those with an inflammatory component. Because the multisubunit I kappa B kinase (IKK) is vital for translating pro-inflammatory stimuli into the activation of NF-kappa B, this kinase provides an opportunity to develop novel therapeutics. In this article, we review the investigations, both genetic and pharmacological, that demonstrate the use of IKK inhibition in autoimmune and inflammatory disorders. It is still unclear what toxicities will be associated with IKK inhibitors; a discussion of the potential for mechanism-based toxicities such as teratogenicity, lymphopoietic defects and susceptibility to infection is also presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据