期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 31, 期 5, 页码 775-824出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2007.02.004
关键词
wakefulness; slow-wave sleep; rapid-eye movement sleep; mammals; wake-promoting structures of the brain; metabolite homeostasis; molecular mechanisms of sleep; history of identification of sleep stages; cellular-molecular-network model of REM sleep; neurotranstnitters
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH059839] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034004, R29NS034004] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH59839, R01 MH059839-09, R01 MH059839] Funding Source: Medline
- NINDS NIH HHS [R01 NS034004-13, NS34004, R01 NS034004, R29 NS034004, R01 NS034004-12] Funding Source: Medline
At its most basic level, the function of mammalian sleep can be described as a restorative process of the brain and body; recently, however, progressive research has revealed a host of vital functions to which sleep is essential. Although many excellent reviews on sleep behavior have been published, none have incorporated contemporary studies examining the molecular mechanisms that govern the various stages of sleep. Utilizing a holistic approach, this review is focused on the basic mechanisms involved in the transition from wakefulness, initiation of sleep and the subsequent generation of slow-wave sleep and rapid eye movement (REM) sleep. Additionally, using recent molecular studies and experimental evidence that provides a direct link to sleep as a behavior, we have developed a new model, the cellular-molecular-network model, explaining the mechanisms responsible for regulating REM sleep. By analyzing the fundamental neurobiological mechanisms responsible for the generation and maintenance of sleep-wake behavior in mammals, we intend to provide a broader understanding of our present knowledge in the field of sleep research. (c) 2007 Elsevier Ltd. All rights reserved.
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