期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 51, 期 4, 页码 333-338出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.062257cc
关键词
chiroptera; Carollia perspicillata; Fgf8; genomic structure; gene expression
资金
- NATIONAL CANCER INSTITUTE [T32CA009299] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [Z01HG000060, Z01HG000196] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [CA09299] Funding Source: Medline
- NICHD NIH HHS [HD97325] Funding Source: Medline
Fibroblast growth factor-8 (Fgf8) encodes a secreted protein which was initially identified as the factor responsible for androgen-dependant growth of mouse mammary carcinoma cells (Tanaka et al., 1992). Fgf8 has been subsequently implicated in the patterning and growth of the gastrulating embryo, paraxial mesoderm (somites), limbs, craniofacial tissues, central nervous system and other organ systems during the development of several vertebrate model animals. Consistent with these findings, Fgf8 is expressed in a complex and dynamic pattern during vertebrate embryogenesis. Here we report the isolation and characterization of a bat (Carollia perspicillata) Fgf8 orthologue. Compared with those of other model vertebrates, Carollia FgfB is conserved with respect to genomic structure, sequence and many domains of developmental expression pattern. Interestingly, the expression domain marking the apical ectodermal ridge of the developing limb shows a striking difference compared to that of mouse, consistent with evolutionary diversification of bat limb morphology.
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