期刊
CANCER JOURNAL
卷 16, 期 4, 页码 374-381出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0b013e3181eb33a6
关键词
immunotherapy; antigen-presenting cell; adoptive immunotherapy; artificial antigen-presenting cell
类别
资金
- Thomsen Family
- Fred Hutchinson Cancer Research Center
- NIH [CA18029, CA114536, AI53193, AI086683-01]
The observation that T cells can recognize and specifically eliminate cancer cells has spurred interest in the development of efficient methods to generate large numbers of T cells with specificity for tumor antigens that can be harnessed for use in cancer therapy. Recent studies have demonstrated that during encounter with tumor antigen, the signals delivered to T cells by professional antigen-presenting cells can affect T-cell programming and their subsequent therapeutic efficacy. This has stimulated efforts to develop artificial antigen-presenting cells that allow optimal control over the signals provided to T cells. In this review, we will discuss the advantages and disadvantages of cellular and acellular artificial antigen-presenting cell systems and their use in T-cell adoptive immunotherapy for cancer.
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