期刊
CANCER INVESTIGATION
卷 32, 期 6, 页码 262-271出版社
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2014.909826
关键词
B7-H3; Primary hepatocellular carcinoma; HepG2; CD8(+) T cells
类别
资金
- Natural Science Foundation of Shandong Province, China [ZR2010HL048]
B7-H3 has been detected in different cancers and correlated to tumor progression and outcome in cancer patients. In this study, we investigated the expression of B7-H3 in tissues and cells of primary hepatocellular carcinoma (PHC) patients. The research showed that B7-H3 is aberrantly expressed in PHC tissues and cells, and its high expression on HepG2 cells significantly promotes cell proliferation, adhesion, migration, and invasion capacity; moreover, it inhibits the proliferation of CD8(+) T cells. Thus, B7-H3 may have a critical role in PHC and it may enhance tumor escape from the immune surveillance of CD8(+) T cells.
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