期刊
CANCER INVESTIGATION
卷 31, 期 5, 页码 330-335出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2013.789905
关键词
Lung cancer; Epidermal growth factor receptor; Tumor tolerance; Dendritic cell; Regulatory T cell
类别
资金
- Guangdong Natural Science Foundation [10451008901005515, 10151008901000177]
The epidermal growth factor receptor (EGFR) has a close relation to lung cancer; its role in the pathogenesis of lung cancer is to be further elucidated. The results of this study indicate that about 80% exosomes purified from the LC biopsies contained EGFR; only about 2% exosomes contained EGFR in the samples from chronic lung inflammation. The purified exosomes induced tolerogenic DCs. Coculture of the tolerogenic DCs and Th0 cells generated the tumor antigen-specific regulatory T cells (Treg). The Tregs could suppress the tumor antigen specific CD8(+) T cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据