期刊
CANCER INVESTIGATION
卷 31, 期 3, 页码 190-196出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2013.775293
关键词
Aggressive pituitary adenoma; Silent GH adenoma; Temozolomide treatment; MGMT
类别
Temozolomide (TMZ) has been proposed as a therapeutic option in aggressive pituitary tumors. Among the published cases, GH expressing tumors were rare. We describe a patient with initially benign silent GH adenoma that transformed into an aggressive GH secreting tumor resistant to usual therapy. MGMT expression was high and the MGMT promoter was unmethylated. Before this aggressive course, patient received three cycles of TMZ; no response was observed. Four cases of GH aggressive tumor treated by TMZ have been reported. Response to TMZ was observed in one of these four patients. Predictive factors of failure of TMZ remain unclear.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据