期刊
CANCER INVESTIGATION
卷 31, 期 2, 页码 111-120出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2012.762781
关键词
Bile Acids; Human Cholangiocarcinoma; NF-kB; IL-6; COX-2
类别
资金
- Shanghai Science and Technology Fund [07ZR14073]
We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice. Further, the phosphorylated IkB was downregulated by free bile acids, and was upregulated by the conjugated bile acids. IL-6 and COX-2 were decreased by the free bile acids and increased by the conjugated bile acids. Collectively, these results suggest that the bile acids regulate the growth of cholangiocarcinoma by modulating NF-kB pathway.
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