期刊
CANCER INVESTIGATION
卷 30, 期 10, 页码 703-711出版社
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2012.732164
关键词
RKIP; Esophageal squamous cell carcinoma; Expression; Methylation
类别
Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition of TE-13 cell proliferation. The promoter hypermethylation of RKIP was found to occur in dysplastic tissues and a close correlation was noted between RKIP methylation and the loss of mRNA and protein expression of the gene in ESCC specimens. In summary, RKIP may act as a tumor suppressor gene in esophageal cancer.
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