期刊
CANCER INVESTIGATION
卷 30, 期 6, 页码 473-480出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2012.681821
关键词
Endometriosis; Inflammation; Iron; Ovarian cancer; Oxidative stress
类别
资金
- KAKENHI (Japan Society for the Promotion of Science (JSPS))
- Grants-in-Aid for Scientific Research [23390391] Funding Source: KAKEN
Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression of ARID1A, PIK3CA, and NF-kB genes has been recognized as the major target genes involved in oxidative stress-induced carcinogenesis. HNF-1beta appears to play a key role in anti-oxidative defense mechanisms. We discuss the pathophysiologic roles of oxidative stress as somatic mutations as well as highly specific agents that effectively modulate these targets.
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