期刊
CANCER INVESTIGATION
卷 30, 期 4, 页码 287-294出版社
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2012.657816
关键词
Axl; Invasion; Multidrug resistance; Leukemia; Breast cancer
类别
资金
- National Natural Science Foundation of China [81071415]
- Natural Science Foundation of Liaoning Province [20102052]
- technological natural fund item of Liaoning Province, China [20092164]
Dysregulation of Axl receptor tyrosine kinases is implicated in the pathogenesis of several sensitive and refractory cancers. In this study we showed that Axl expression was upregulated in drug-resistant cancer cells, as compared to those in parental cells. Downregulation of Axl expression by RNAi led to a decrease of K562/ADR and MCF-7/ADR cells invasion, proliferation in soft agar, and increased cells chemosensitivity in vitro. In nude mice bearing xenografts, downregulation of Axl in MDR cells enhanced the anticancer activity of intraperitoneally applied chemotherapeutic drugs. Our observations suggest that Axl represents a promising gene for overcoming MDR in cancer therapy.
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