期刊
CANCER INVESTIGATION
卷 30, 期 4, 页码 251-257出版社
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2012.657817
关键词
Colorectal cancer; PMCA; Signal transduction
类别
资金
- Institute of Pathologie Nordhessen
The expression of the plasmamembrane Ca2+ ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n=32), adenoma (n=19), adenocarcinoma (n=27), and lymph node metastasis (n=6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, and (iii) quantitative reverse-transcriptase PCR. Amarked reduction of PMCA4 protein was observed in high-grade adenoma, colon cancer as well as lymph node metastasis, pointing to its potential role in the progression of cancer. However, PMCA4 RNA transcripts were unchanged or even increased in colon carcinomas, suggesting posttranscriptional regulation of PMCA4 during carcinogenesis.
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