期刊
CANCER INVESTIGATION
卷 30, 期 1, 页码 72-78出版社
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2011.630051
关键词
Clusterin; Colorectal cancer; Caco-2; SW-480; SW-620
类别
资金
- Fondo de Investigaciones Sanitarias (FIS) [PS09/00405]
- Xunta de Galicia [10PXIB310215PR]
- FEDER
We studied the specific changes of the secreted protein clusterin and its cytoplasmic precursor regarding colorectal tumorigenesis, using in vitro differentiation of Caco-2 cells. In tumor-like stage, we observed an overexpression of both precursor and secreted clusterin, corroborated in the cell line SW-480. Noticeably, SW-620 cells (from a tumoral node, thus with metastatic capacity) did not show overexpression of either precursor or secreted clusterin, suggesting a downregulation related to local metastasis. We further investigated clusterin in serum, finding a significant increase in colorectal cancer patients, with 81% sensitivity, 79% specificity, and an area under the ROC curve of 0.85.
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