期刊
CANCER INVESTIGATION
卷 29, 期 8, 页码 542-547出版社
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2011.606251
关键词
CD151; Colorectal cancer; Hypoxia; Tetraspanin family
类别
资金
- National Cheng Kung University Medical Institute and Hospital, Tainan, Taiwan
Purpose: Tomeasure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.
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