期刊
CANCER INVESTIGATION
卷 29, 期 3, 页码 187-195出版社
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2010.512605
关键词
Polycomb group proteins; Cancer; Epigenetics
类别
资金
- National Natural Science Foundation of China [30830055]
Cancer not only is associated with inherited genetic sequences but also results from epigenetic changes. Thus, understanding the mechanisms underlying epigenetic modifications is important for cancer prevention, diagnosis, and therapy. There is much evidence showing that some Polycomb group (PcG) proteins are abnormally expressed in certain tumors. This review addresses biological functions and biochemical behaviors of the Polycomb repression complex proteins, including their enzymatic activities. Additionally, the potential mechanisms of PcG gene silencing by PcG and its link to cancers are summarized that will shed light on this novel area of study in cancer.
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