期刊
NATURAL PRODUCT REPORTS
卷 24, 期 5, 页码 972-987出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b703107f
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资金
- BBSRC [BB/D003997/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D003997/1] Funding Source: Medline
The evolution of metabolic pathways is discussed with reference to the biosynthesis of a number of vitamins and cofactors. Retrograde and patchwork models are highlighted and their relevance to our knowledge of pathway processes and enzymes is examined. Pathway complexity is explained in terms of the acquisition of broad specificity enzymes.
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