期刊
CANCER INVESTIGATION
卷 28, 期 10, 页码 993-1003出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2010.483503
关键词
Autocrine motility factor receptor; Rho-associated protein kinase 2; Invasion; Esophageal squamous cell cancer
类别
资金
- Science and Technology of Education Ministry of China [00190]
- Education Ministry of China [00190, 2002-2]
- National Natural Science Foundation of China [30700014]
Aberrant overexpression of autocrine motility factor and its receptor (AMFR) is observed in many cancers but not in esophageal squamous cell cancer (ESCC). In this study, upregulated rho-associated protein kinase 2, p-cofilin and intracellular adhesion molecule-1, and downregulated E-cadherin were found in ESCC cells transfected with the plasmid pcDNA 3.1-AMFR-C, while opposite results were observed in ESCC cells transfected with siRNA against AMFR. Additionally, an elevated invasion of ESCC cells by AMFR was reversed by rho-associated protein kinase 2 inhibitor Y-27632, suggesting that AMFR pathway promotes invasion of ESCC cells and may be a potential target for ESCC therapy.
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