期刊
CANCER INVESTIGATION
卷 29, 期 1, 页码 42-48出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2010.512597
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资金
- Department of Science and Technology, Government of India
- Council of Scientific and Industrial Research
- Department of Biotechnology, India
Proteins do not operate as individual units, and components of intracellular canonical pathways often cross talk in tumor genesis. We hypothesized that G-protein-coupled receptor 56 (GPR56), transglutaminase (TG2), and nuclear factor-kappa B (NF-kappa B) may collaborate in interconnected pathways and contribute to the aggressive behavior of esophageal squamous cell carcinoma (ESCC). Immunohistochemical analysis of GPR56, TG2, and NF-kappa B was carried out using ESCC tissue microarrays. Immunostaining of all the three proteins revealed a significant increase in their expression in ESCCs as compared with normal epithelia and correlated with their concomitant expression. A significant correlation between GPR56, TG2, and NF-kappa B was observed that correlated with nodal metastasis and tumor invasion in ESCCs.
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