期刊
LETTERS IN DRUG DESIGN & DISCOVERY
卷 4, 期 8, 页码 596-604出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018007782794482
关键词
pyrrolo[2,1-c][1,4]benzodiazepines; 6-chloropurine nucleosides; DNA-binding affinity; anticancer activity
New A-C8 and C-C2-linked 6-chloropurine-pyrrolo[2,1-c][1,4]benzodiazepine hybrids have been prepared and evaluated for their anticancer potential. The molecular modeling studies might be explained in terms of effect of the molecule on binding in the minor groove of DNA and also comparison to both A-C8/ C-C2-position of the PBD. These PBD conjugates have shown DNA-binding ability and promising anticancer activity.
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