期刊
CANCER INVESTIGATION
卷 27, 期 10, 页码 1016-1022出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357900902849640
关键词
Thymosin beta 10; Actin; Cancer; Apoptosis; Angiogenesis; Thymosin beta 4
类别
资金
- Michael E. DeBakey Department of Surgery at the Baylor College of Medicine, Houston, Texas, USA
- University Mobility in Asia and the Pacific (UMAP)
Thymosin beta 10 (T beta 10) is a member of the beta-thymosin family, which has biological activities as an actin-sequestering protein involved in cell motility. T beta 10 may be correlated with tumor biology such as cell proliferation, apoptosis, angiogenesis, and metastasis behavior. However, the molecular mechanisms of action of T beta 10 in cancer are largely unknown. T beta 10 is differentially expressed in embryogenesis and neuronal development. Its expression is also increased in many inflammatory conditions and tumorigenesis. This review briefly summarizes recent advances in T beta 10 research including differential expression, functions, mechanisms, gene regulation, and therapeutic applications in cancer, wound healing, and other diseases.
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