期刊
CANCER INVESTIGATION
卷 27, 期 8, 页码 851-856出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900902744528
关键词
Bevacizumab; Erythropoiesis; Increased hemoglobin; Renal cell carcinoma; VEGF inhibition
类别
资金
- NIH [1 R01 HL074267-01]
- NCI/NIH [T32 CA009287]
- NATIONAL CANCER INSTITUTE [T32CA009287] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL074267] Funding Source: NIH RePORTER
We retrospectively analyzed whether increased hemoglobin is a surrogate biomarker of efficacy for vascular endothelial growth factor (VEGF) inhibitors in advanced renal cell carcinoma (RCC) patients. Twelve patients were identified who had received bevacizumab alone or as combination therapy. Eleven patients experienced a rise in hemoglobin. Median change was 1.6 g/dL (0-4.0). Degree of peak increase correlated with longer progression-free survival (PFS) in metastatic patients: increase of 15% yielded a 3.1-month median PFS compared to 8.2 months with rises 15%. This study identifies increased hemoglobin as a possible consequence of VEGF inhibitors. The correlation with longer PFS suggests that rise in hemoglobin may be a surrogate biomarker of efficacy.
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