期刊
CANCER INVESTIGATION
卷 27, 期 7, 页码 747-755出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802672746
关键词
Pancreatic cancer; Proteomics; Two-dimensional electrophoresis; Hypoxia; Glucose-regulated protein 78; Macrophage migration inhibitory factor; Annexin A5
类别
资金
- Key Project of Department of Science & Technology of Shandong Province, China [2005GG1102003]
We identified a group of hypoxia-regulated proteins upregulated in microdissected pancreatic cancer nests compared with normal pancreatic ducts. Immunohistochemical study further validated that pancreatic cancers had significantly higher expression levels of glucose-regulated protein 78, macrophage migration inhibitory factor and annexin A5 than normal pancreas tissues, these protein biomarkers also demonstrated high receiver operating characteristic curves in discriminating pancreatic cancers from normal pancreas. In conclusion, our study indicated a link between pancreatic cancer and hypoxia-regulated proteins. Glucose-regulated protein 78, macrophage migration inhibitory factor and annexin A5 might be promising targets for pancreatic cancer diagnosis and therapy.
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