期刊
CLINICS IN DERMATOLOGY
卷 25, 期 1, 页码 9-18出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2006.09.007
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资金
- NIAMS NIH HHS [R03 AR048648-03, R03 AR048648] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R03AR048648] Funding Source: NIH RePORTER
Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis. (C) 2007 Elsevier Inc. All rights reserved.
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