期刊
CANCER INVESTIGATION
卷 27, 期 2, 页码 193-200出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802172093
关键词
Esophageal neoplasms; Neoadjuvant therapy; Capecitabine; Oxaliplatin; Gene expression
类别
Purpose: To determine the maximal tolerated dose of capecitabine with oxaliplatin + radiotherapy in a phase I study of localized esophageal cancer. Patients and Methods: Oxaliplatin (85 mg/m2) administered on days 1, 15, and 29. Capecitabine administered twice daily 5 days weekly; dose levels (DL) were 1, 1000; 2, 1250; and 3, 1500 mg/m2 with 50.4 Gy radiation. Results: Dose-limiting toxicity was reached at DL 3. Carboxylesterase expression in day 2 tumor specimens and induction correlated with response (p 0.05). Conclusion: The maximal tolerated dose was 85 mg/m2 of oxaliplatin, 1,250 mg/m2/day of capecitabine, and 50.4 Gy of radiation.
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