期刊
CANCER INVESTIGATION
卷 26, 期 10, 页码 1008-1014出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802087267
关键词
Resistin; Protein expression; Colorectal cancer; Polymorphism
类别
资金
- Futurum-the academy of healthcare
- County Council of Jonkoping, Sweden
- University College of Health Sciences, Jonkoping, Sweden
A single nucleotide polymorphism (SNP) -420C> G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420C> G resistin polymorphism is not a potential genetic susceptibility factor.
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