期刊
MEDICAL MYCOLOGY
卷 45, 期 6, 页码 513-518出版社
OXFORD UNIV PRESS
DOI: 10.1080/13693780701390140
关键词
cryptococcosis; candidate gene association studies; genetic polymorphisms; haplotype analysis; Cryptococcus neoformans
资金
- Intramural NIH HHS Funding Source: Medline
- NATIONAL CANCER INSTITUTE [ZIASC006830, Z01SC010083, Z01SC006830] Funding Source: NIH RePORTER
A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.
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