期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 128, 期 1, 页码 112-116出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2006.11.023
关键词
heart; aging; arrhythmia; heart failure; hypoxia; K-ATP channel
资金
- NHLBI NIH HHS [R01 HL054732] Funding Source: Medline
- NIA NIH HHS [P01 AG015434] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL054732] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG015434] Funding Source: NIH RePORTER
We have begun to study the genetic basis of deterioration of cardiac function in the fruit fly Drosophila melanogaster as an age-related cardiac disease model. For this purpose we have developed heart function assays in Drosophila and found that the fly's cardiac performance, as that of the human heart, deteriorates with age: aging fruit flies exhibit a progressive increase in electrical pacing-induced heart failure as well as in arrhythmias. The insulin receptor and associated pathways have a dramatic and heart-autonomous influence on age-related cardiac performance in flies, suggestive of potentially similar mechanisms in regulating cardiac aging in vertebrates. Compromised KCNQ and K-ATP ion channel functions also seem to contribute to the decline in heart performance in aging flies, suggesting that the corresponding vertebrate gene functions may similarly decline with age, in addition to their conserved role in protecting against arrhythmias and hypoxia/ischemia, respectively. The fly heart is thus emerging as a promising genetic model for studying the age-dependent decline in organ function. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据