期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 63, 期 3, 页码 199-213出版社
SPRINGER
DOI: 10.1007/s00262-013-1509-4
关键词
Tumor immunity; NKT cells; Regulatory T cells (Treg); Interaction among regulatory cells
资金
- National Cancer Institute, NIH
- Gui Foundation
NKT cells are CD1d-restricted T cells that recognize lipid antigens. They also have been shown to play critical roles in the regulation of immune responses. In the immune responses against tumors, two subsets of NKT cells, type I and type II, play opposing roles and cross-regulate each other. As members of both the innate and adaptive immune systems, which form a network of multiple components, they also interact with other immune components. Here, we discuss the function of NKT cells in tumor immunity and their interaction with other regulatory cells, especially CD4(+)CD25(+)Foxp3(+) regulatory T cells.
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