期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 63, 期 8, 页码 807-819出版社
SPRINGER
DOI: 10.1007/s00262-014-1555-6
关键词
Regulatory T cells; Tumor-infiltrating lymphocytes; Colorectal cancer; APC(Min/+); Anti-tumor immunity; Chemokines
资金
- Swedish Research Council
- Swedish Cancer Foundation
- Sahlgrenska University Hospital
- Swedish Society of Medicine
- Ruth and Richard Julin foundation
- Assar Gabrielssons foundation
- Wilhelm and Martina Lundgren's foundation
- Sigurd and Elsa Goljes foundation
- Olle Engkvist's foundation
- Hvitfeldska foundation
Tumor progression in the colon moves from aberrant crypt foci to adenomatous polyps to invasive carcinomas. The composition of the tumor-infiltrating leukocyte population affects the ability of the immune system to fight the tumor. T cell infiltration into colorectal adenocarcinomas, particularly T helper 1 (Th1) type T cells as well as increased regulatory T cell (Treg) frequencies, is correlated with improved prognosis. However, whether Th1 cells and Tregs are already present at the adenoma stage is not known. In this study, the APC(Min/+) mouse model of intestinal adenomatous polyposis was used to investigate tumor-associated lymphocyte subsets and the mechanisms of their accumulation into gastrointestinal adenomas. Compared to unaffected tissue, adenomas accumulated CD4(+)FoxP3(+) putative Treg in parallel with lower frequencies of conventional T cells and B cells. The accumulation of Treg was also observed in human adenomatous polyps. Despite high Treg numbers, the function of conventional T cells present in the APC(Min/+) adenomas was not different from those in the unaffected tissue. Adenomas displayed an altered chemokine balance, with higher CCL17 and lower CXCL11 and CCL25 expression than in the unaffected tissue. In parallel, CXCR3(+) Tregs were largely absent from adenomas. The data indicate that already in early stages of tumor development, the balance of lymphocyte-recruiting chemokines is altered possibly contributing to the observed shift toward higher frequencies of Treg.
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