期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 61, 期 8, 页码 1327-1341出版社
SPRINGER
DOI: 10.1007/s00262-012-1293-6
关键词
Cancer; Co-stimulation; B7 family; PIVAC11; Therapy
资金
- Mildred Scheel Foundation, Bonn
The modulation and suppression of anti-tumor immune responses is a characteristic feature of tumor cells to escape immune surveillance. Members of the B7 family are involved in this process, since the level of activation of the anti-tumor immune response depends on the balance between co-stimulatory and co-inhibitory signals. Some molecules are often overexpressed in tumors, which has been associated with the pathogenesis and progression of malignancies as well as their immunological and non-immunological functions. The B7 homologs play a key role in the maintenance of self-tolerance and the regulation of both innate and adaptive immunity in tumor-bearing hosts. Furthermore, the blockade of negative signals mediated by the interaction of co-inhibitory ligands and counter-receptors of the B7 family is currently being studied as a potential immunotherapeutic strategy for the treatment of cancer in humans.
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