期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 51, 期 6-7, 页码 447-461出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.072327as
关键词
BMP; ear; ectoderm; epibranchial; eye; FGF; olfactory epithelium; sensory placodes; Wnt
The otic primordium belongs to a group of related structures, the sensory placodes that contribute to the paired sense organs - ear, eye and olfactory epithelium - and to the distal parts of the cranial sensory ganglia. Recent evidence suggests that despite their diversity, all placodes share a common developmental origin and a common molecular mechanism which initiates their formation. At the base of placode induction lies the specification of a unique placode field, termed the preplacodal region and acquisition of this preplacodal state is required for ectodermal cells to undergo otic development. Here I review the molecular mechanisms that sequentially subdivide the ectoderm to give rise to the placode territory.
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