期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 59, 期 4, 页码 489-510出版社
SPRINGER
DOI: 10.1007/s00262-009-0804-6
关键词
Interferon regulatory factor; Host defense; Transcriptional regulation; Immunity; Oncogenesis
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.
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