期刊
TRENDS IN CELL BIOLOGY
卷 17, 期 9, 页码 438-447出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2007.06.007
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资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS037352] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS037352-09] Funding Source: Medline
The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates sternness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.
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