期刊
CLINICAL AUTONOMIC RESEARCH
卷 17, 期 2, 页码 118-121出版社
DR DIETRICH STEINKOPFF VERLAG
DOI: 10.1007/s10286-007-0396-1
关键词
Parkinson disease; sympathetic nervous system; baroreflex; heart; imaging techniques; autonomic nervous system
资金
- Intramural NIH HHS [Z99 NS999999] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [Z01HD008735] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [Z01NS003034, Z01NS003033] Funding Source: NIH RePORTER
There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[F-18]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.
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