The prolactin family: effectors of pregnancy-dependent adaptations

Prolactin (PRL) is a hormone involved in many biological functions. In some species, there is a family of PRL-related genes; such is the case in the mouse and rat. The actions of members of the PRL family can be distinguished based on the involvement of the PRL receptor signaling pathway (classical versus nonclassical). Recent insights into the biology of the PRL family have been derived from mouse mutagenesis studies. There is compelling evidence suggesting that the PRL family contributes to the regulation of pregnancy-dependent adaptations to physiological stressors.