期刊
TRENDS IN CELL BIOLOGY
卷 17, 期 3, 页码 145-156出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2007.01.003
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资金
- NATIONAL CANCER INSTITUTE [P01CA100324, P30CA013330] Funding Source: NIH RePORTER
- NCI NIH HHS [CA32331, P01 CA100324, P30 CA13330, R01S CA25604] Funding Source: Medline
Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 homology' (PCH) family of adaptor proteins has recently been shown to coordinate the membrane and cytoskeletal dynamics involved in these processes by curving membranes, recruiting dynamin and controlling the architecture of the actin cytoskeleton. Mutations in PCH family members or proteins that interact with them are associated with autoinflammatory, neurological or neoplastic diseases. Here, we review the nature, actions and disease associations of the vertebrate PCH family members, highlighting their fundamental roles in the regulation of processes involving membrane-cytoskeletal interactions.
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