期刊
CANCER GENETICS AND CYTOGENETICS
卷 183, 期 2, 页码 105-108出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergencyto.2008.02.005
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We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different. (C) 2008 Elsevier Inc. All rights reserved.
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