Amphiphilic dendrimeric peptides as model non-sequential pharmacophores with antimicrobial properties

A concept of application of dendrimer chemistry for construction of 'non-sequential pharmacophore', mimicking active conformation of linear antimicrobial peptides, is introduced. It resulted in the synthesis of a family of low-molecular-weight basic peptide dendrimers with antimicrobial properties against Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and Candida albicans. Copyright (c) 2007 S. Karger AG, Basel.