期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 23, 期 11, 页码 2447-2454出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-14-0247
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资金
- Helmholtz Association
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Danish Cancer Society (Denmark)
- Ligue Contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- INSERM (France)
- Deutsche Krebshilfe (Germany)
- Deutsches Krebsforschungszentrum (Germany)
- Federal Ministry of Education and Research (Germany)
- Hellenic Health Foundation (Greece)
- Stavros Niarchos Foundation (Greece)
- Hellenic Ministry of Health and Social Solidarity (Greece)
- Italian Association for Research on Cancer (Associazione Italiana per la Ricerca sul Cancro) (Italy)
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare, and Sports (VWS) (the Netherlands)
- Netherlands Cancer Registry (NKR) (the Netherlands)
- LK Research Funds (the Netherlands)
- Dutch Prevention Funds (the Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland) (the Netherlands)
- World Cancer Research Fund (WCRF) (the Netherlands)
- Statistics Netherlands (the Netherlands)
- ERC-AdG (Norway) [232997]
- Nordforsk, Nordic Centre of Excellence Programme on Food, Nutrition and Health (Norway)
- Health Research Fund (FIS) (Spain)
- Regional Government of Andalucia (Spain)
- ISCIII RETIC (Spain) [RD06/0020]
- Swedish Cancer Society (Sweden)
- Swedish Scientific Council (Sweden)
- Regional Government of Skane (Sweden)
- Cancer Research UK (United Kingdom)
- Medical Research Council (United Kingdom)
- Stroke Association (United Kingdom)
- British Heart Foundation (United Kingdom)
- Department of Health (United Kingdom)
- Wellcome Trust (United Kingdom)
- Food Standards Agency (United Kingdom)
- Regional Government of Asturias (Spain)
- Regional Government of Basque Country (Spain)
- Regional Government of Murcia (Spain)
- Regional Government of Navarra (Spain)
- Regional Government Vasterbotten (Sweden)
- Cancer Research UK [14136, 16491] Funding Source: researchfish
- Medical Research Council [G1000143, G0401527] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114] Funding Source: researchfish
Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk; the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: We measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59 +/- 0.20) than in controls (0.57 +/- 0.17), although this difference was not statistically significant (P = 0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk [OR, 1.13; 95% confidence interval (CI), 1.01-1.27]. Additional analyses by cubic spline regression suggested a possible nonlinear relationship between LTL and pancreatic cancer risk (P = 0.022), with a statistically nonsignificant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this article can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk. (C)2014 AACR.
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