期刊
NEUROEPIDEMIOLOGY
卷 29, 期 3-4, 页码 208-212出版社
KARGER
DOI: 10.1159/000111584
关键词
essential tremor,age of onset; epidemiology; essential tremor; bimodal
资金
- NCRR NIH HHS [M01 RR000645, RR00645] Funding Source: Medline
- NIEHS NIH HHS [P30 ES09089, P30 ES009089] Funding Source: Medline
- NINDS NIH HHS [R01 NS39422, R01 NS039422] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000645] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES009089] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS039422] Funding Source: NIH RePORTER
Background/Aims: The distribution of age of onset of essential tremor (ET) is unclear, with discrepancies in the literature. Some data suggest a bimodal distribution and other data 1 late-life peak. We studied age of ET onset in 2 distinct settings: a population-based study and a tertiary referral center. Methods: Age of onset data were collected. Results: In the population, there was only a small peak at the age of <= 30 years (14.1% of cases) but a clear peak in later life (85.9% of cases). In the tertiary referral center, a bimodal distribution was apparent with 1 large peak (42.2% of cases) at the age of <= 40 years and the second large peak (57.8% of cases) in later life. Familial cases accounted for only 52.6% of young-on-set cases from the population, yet 82.7% from the tertiary center. Discussion: In the population-based study, a peak in later life was clearly present but a young-onset peak was barely discernable, comprising few cases. By contrast, in a tertiary referral center, age of onset was clearly bimodal. While age of ET onset is often said to be bimodal, this may be due to the preferential referral to tertiary centers of patients with young-onset, familial ET. Copyright (c) 2007 S. Karger AG, Basel.
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