期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 24, 期 2, 页码 448-453出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-14-1076
关键词
-
资金
- NIH [CA-23108, CA-046927, CA-059005]
- K07 Career Development Award [CA106269]
Background: Blacks have a higher incidence of colorectal cancer and a younger age at diagnosis compared with whites. Few studies have investigated racial differences in risk of meta-chronous adenomas and serrated polyps and whether this risk differs by polyp characteristics or age of patient. Methods: We analyzed data pooled from three placebo-controlled adenoma chemoprevention trials to explore racial differences in the risk of large bowel polyps in patients <= 50 and >50 years of age. Using generalized linear regression, we estimated risk ratios (RR) and 95% confidence intervals (CI) as measures of the association between race and risk of one or more adenomas or serrated polyps after randomization. Results: Among the 2,605 subjects who completed at least one follow-up exam, blacks <= 50 years of age had a higher risk of any conventional adenoma (RR, 1.70; 95% CI, 0.99-2.92) and advanced neoplasms (RR, 4.05; 95% CI, 1.43-11.46) and a nonsignificantly lower risk of serrated polyps (RR, 0.75; 95% CI, 0.34-1.62) compared with whites. Among patients >50 years, there was no racial difference in risk of adenomas (RR, 1.08; 95% CI, 0.92-1.27) or advanced neoplasms (RR, 1.05; 95% CI, 0.71-1.56). However, blacks had a significantly lower risk of serrated polyps (RR, 0.65; 95% CI, 0.49-0.87) than whites. Conclusions: Our results demonstrate a higher risk of meta-chronous adenomas in blacks compared with whites at younger ages. Impact: Our results suggest that the racial disparity in colorectal cancer incidence may be due to an excess of neoplasia in younger blacks. (C)2014 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据